DSIP
Endogenous sleep peptide — reduces cortisol, promotes restorative delta-wave sleep, and modulates stress responses.
Research facts
| Half-life | ~1–2h |
|---|---|
| Route | SubQ / Nasal |
| Typical dose | 100–300 mcg |
| Frequency | 30–60 minutes before sleep |
| Solvent | Bacteriostatic water |
| pH | 5.5–7.5 |
| Stability | 30 days at +4°C |
Mechanism of action
DSIP is an endogenous nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit thalamus during slow-wave sleep. It modulates sleep architecture by enhancing delta-wave (slow-wave) sleep, reducing sleep latency, and normalising disrupted sleep patterns. DSIP interacts with opioidergic systems (µ-opioid receptors) and has anti-stress effects via inhibition of ACTH and cortisol release. It also exhibits antioxidant properties (scavenging reactive oxygen species) and has been studied for alcohol and opiate withdrawal management. Its anti-pain effects in chronic pain models are mediated via endogenous opioid pathways.
Documented effects (research-model)
- Delta-wave (slow-wave) sleep promotion
- Sleep latency reduction
- Cortisol and ACTH inhibition (anti-stress)
- Chronic pain modulation via opioid pathways
- Potential application in withdrawal protocols
- Antioxidant activity
Research protocols
| Protocol | Dose | Frequency | Cycle | Vial |
|---|---|---|---|---|
| Standard | 100–300 mcg SubQ | 30–60 mins before sleep | 2–4 weeks as needed | 5mg / 5mL BAC water |
Research context only. Not medical advice. Consult a qualified healthcare professional before any protocol decision.
Synergies
- Epitalon HIGH
Epitalon (circadian clock reset, melatonin) + DSIP (delta sleep induction, cortisol reduction). Comprehensive sleep and longevity stack. - Sermorelin MODERATE
Sermorelin elevates GH during slow-wave sleep; DSIP deepens delta-wave sleep. Enhanced GH pulse via deeper sleep architecture.
Myths & misconceptions
Evidence gaps
- Inconsistent results across studies — some human trials show effect, others do not.
- Rapid degradation in plasma questions whether administered DSIP reaches target tissues intact.
- Optimal delivery route (SubQ vs. nasal) for sleep effects not established.
Safety notes
Well-tolerated in limited human studies. No significant adverse events reported. Short-term use appears safe. Long-term research lacking. Research context only.
Biomarkers to monitor
Primary-source citations
- PMID 6318757 — Delta sleep-inducing peptide: a review of its effects on sleep, body temperature and circadian rhythm (Peptides. 1982)
Frequently asked
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide — Nonapeptide) is a research compound classified in our library as Tier D — Animal or in-vitro data only.. Endogenous sleep peptide — reduces cortisol, promotes restorative delta-wave sleep, and modulates stress responses.
What is the evidence tier for DSIP?
We classify DSIP as Tier D: Animal or in-vitro data only. See our full peptide evidence tiers explainer for how we assign S/A/B/C/D.
What is the research dose of DSIP?
For DSIP, typical research dose is 100–300 mcg, route is SubQ / Nasal, half-life is ~1–2h. Protocols vary by research goal — see the protocols section on this page for standard and advanced dosing schedules. Research use only, not medical advice.
What does DSIP stack well with?
DSIP stacks well with Epitalon. Epitalon (circadian clock reset, melatonin) + DSIP (delta sleep induction, cortisol reduction). Comprehensive sleep and longevity stack.
Is DSIP safe?
Well-tolerated in limited human studies. No significant adverse events reported. Research context only — no compound on this site is approved for human therapeutic use unless explicitly noted.