Pinealon
Pineal gland peptide bioregulator — epigenetic gene expression, circadian rhythm support, and neuroprotection.
Research facts
| Half-life | ~2–4h |
|---|---|
| Route | SubQ / Oral |
| Typical dose | 100–300 mcg/day |
| Frequency | Once daily (evening) |
| Solvent | Bacteriostatic water |
| pH | 5.5–7.5 |
| Stability | 30 days at +4°C |
Mechanism of action
Pinealon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) from the Khavinson peptide bioregulator series, derived from the bovine pineal gland. Like Epitalon (from the same Khavinson research group), Pinealon exerts gene-regulatory effects by binding directly to DNA promoter regions and modulating transcription of genes involved in antioxidant defence, circadian rhythm regulation, and neuroprotection. It has been studied for improving cognitive function in elderly subjects, reducing neuronal damage in models of ischaemia and hypoxia, and regulating melatonin-related gene expression in the pineal gland. The primary hypothesis is that age-related pineal degeneration contributes to neurological decline, and Pinealon partially compensates for this.
Documented effects (research-model)
- Neuroprotection via gene expression modulation
- Circadian rhythm and sleep architecture support
- Antioxidant enzyme upregulation in neural tissue
- Cognitive protection in ageing models
- Potential synergy with melatonin signalling
Research protocols
| Protocol | Dose | Frequency | Cycle | Vial |
|---|---|---|---|---|
| Standard | 100–200 mcg/day | Once daily SubQ (evening) | 10 days on, 4 months off (Khavinson protocol) | 5mg / 5mL BAC water |
Research context only. Not medical advice. Consult a qualified healthcare professional before any protocol decision.
Synergies
- Epitalon HIGH
Epitalon (pineal/telomere-focused) + Pinealon (pineal/neuroprotection). Both from Khavinson series — designed to be used together in longevity protocols. - DSIP MODERATE
Both influence sleep and circadian biology. Pinealon (pineal regulation) + DSIP (delta sleep induction). Complementary sleep-focused stack.
Myths & misconceptions
Evidence gaps
- Minimal published human research — almost all data from Russian-language animal and in vitro studies.
- Optimal cycle length and long-term effects not established.
- Mechanism of neuroprotection not definitively characterised in humans.
Safety notes
Very limited human safety data. Based on the Khavinson bioregulator safety profile, short cycles (10 days) with long washout periods (4 months) are the standard protocol. Research context only.
Biomarkers to monitor
Primary-source citations
- PMID 22394539 — Peptide bioregulators derived from pineal gland: effects on neurological function (Neuro Endocrinol Lett. 2012)
Frequently asked
What is Pinealon?
Pinealon (Ala-Glu-Asp-Gly — Pineal Gland-Derived Tetrapeptide) is a research compound classified in our library as Tier D — Animal or in-vitro data only.. Pineal gland peptide bioregulator — epigenetic gene expression, circadian rhythm support, and neuroprotection.
What is the evidence tier for Pinealon?
We classify Pinealon as Tier D: Animal or in-vitro data only. See our full peptide evidence tiers explainer for how we assign S/A/B/C/D.
What is the research dose of Pinealon?
For Pinealon, typical research dose is 100–300 mcg/day, route is SubQ / Oral, half-life is ~2–4h. Protocols vary by research goal — see the protocols section on this page for standard and advanced dosing schedules. Research use only, not medical advice.
What does Pinealon stack well with?
Pinealon stacks well with Epitalon. Epitalon (pineal/telomere-focused) + Pinealon (pineal/neuroprotection). Both from Khavinson series — designed to be used together in longevity protocols.
Is Pinealon safe?
Very limited human safety data. Based on the Khavinson bioregulator safety profile, short cycles (10 days) with long washout periods (4 months) are the standard protocol. Research context only — no compound on this site is approved for human therapeutic use unless explicitly noted.